Vascular replacement using a layered elastin-collagen vascular graft in a porcine model: one week patency versus one month occlusion

Development of a reinforced porcine elastin composite vascular scaffold.

Elastin, a principal structural component of native arteries, has distinct biological and mechanical advantages when used as a biomaterial; however, its low ultimate tensile strength has limited its use as an arterial conduit. We have developed a scaffold, consisting of a purified elastin tubular conduit strengthened with fibrin bonded layers of acellular small intestinal submucosa (aSIS) for p...

A generalization of Profile Hidden Markov Model (PHMM) using one-by-one dependency between sequences

The Profile Hidden Markov Model (PHMM) can be poor at capturing dependency between observations because of the statistical assumptions it makes. To overcome this limitation, the dependency between residues in a multiple sequence alignment (MSA) which is the representative of a PHMM can be combined with the PHMM. Based on the fact that sequences appearing in the final MSA are written based on th...

Forecasts covering one month using a cut - cell model

Electrospinning collagen and elastin: preliminary vascular tissue engineering.

Significant challenges must be overcome before the true benefit and economic impact of vascular tissue engineering can be fully realized. Toward that end, we have pioneered the electrospinning of micro- and nano-fibrous scaffoldings from the natural polymers collagen and elastin and applied these to development of biomimicking vascular tissue engineered constructs. The vascular wall composition...

Highly Aligned Elastin Incorporated Collagen Fibers for Vascular Tissue Engineering

Introduction: Coronary artery disease caused by atherosclerosis is a significant health problem worldwide. In the United States alone, over 370,000 people die from the disease each year [1]. The current gold standard for the treatment of coronary artery disease is the transplantation of autologous blood vessels. However, lack of sufficient donor tissue and donor-site morbidity are major limitat...